General Hospital spoilers for the week of September 22-26, 2025 tease a goodbye to a Port Charles legend.
Port Charles Says Goodbye to Monica
While Jason (Steve Burton) and Tracy (Jane Elliot) kept the news of Monica’s (the late Leslie Charleson) to themselves as they processed their grief, the rest of Port Charles is about to learn of the Quartermaine matriarch’s passing. Sonny (Maurice Benard) and Carly (Laura Wright) will receive the sad news on Monday, while Martin (Michael E. Knight) will make a mysterious phone call after he finds out. Could this be to the person who wrote Monica a letter she never received?
By Thursday, it will be time to say goodbye to Monica and pay tribute to her portrayer. But as the memorial continues on Friday, a surprise guest will show up. Many may think this is One Life To Live alums Erika Slezak’s debut, but considering the actress only began taping last week, odds are it won’t be her.
Drew’s New Plan
Tuesday will see Drew (Cameron Mathison) issue new orders. There’s no telling what this entails or who it will hurt, but since he’s now carrying the grief of his mother along with everything else, Port Charles’ most hated man could become unstoppable. His latest scheme may involve Portia (Brook Kerr), who will once again seek out Isaiah (Sawandi Wilson) mid-week, while Trina (Tabyana Ali) has questions for Jordan (Tanisha Harper).
Odds and Ends
Anna (Finola Hughes) will start the week with some shocking Intel, presumably involving Drew’s shooting, while Britt (Kelly Thiebaud) winds up shaken and guilty.
Meanwhile, Felicia (Kristina Wagner) will worry about her grandson, as James (Gary James Fuller) hasn’t been handling his mother’s illness well. He blames himself for Maxie’s (Kirsten Storms) heart attack, leaving his loved ones to pick up the pieces.
